Mypn^tm1Mbng
Targeted Allele Detail

Summary

• Symbol: Mypn^tm1Mbng
• Name: myopalladin; targeted mutation 1, Marie-Louise Bang
• MGI ID: MGI:6856680
• Synonyms: MKO
• Gene: Mypn Location: Chr10:62951574-63039731 bp, - strand Genetic Position: Chr10, 32.54 cM
• Alliance: Mypn^tm1Mbng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317661
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A Mypn start codon in exon 2 followed by a LacZ-neomycin cassette via homologous recombination in ES cells. Aberration of the Mypn gene was confirmed by northern blot analysis and western blot analysis. It is a null allele. (J:317661)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mypn Mutation: 75 strains or lines available

References

• Original: J:317661 Filomena MC, et al., Myopalladin promotes muscle growth through modulation of the serum response factor pathway. J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):169-194
• All: 2 reference(s)