Chd8^em1Anord
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chd8^em1Anord
• Name: chromodomain helicase DNA binding protein 8; endonuclease-mediated mutation, Alexander S Nord
• MGI ID: MGI:6856639
• Synonyms: Chd8^del5
• Gene: Chd8 Location: Chr14:52435608-52495237 bp, - strand Genetic Position: Chr14, 26.84 cM
• Alliance: Chd8^em1Anord page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted 5-bp deletion (mm9: chr14:52,847,25952,847,263) causing a frameshift mutation and truncation. (J:249066)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd8 Mutation: 108 strains or lines available

References

• Original: J:249066 Gompers AL, et al., Germline Chd8 haploinsufficiency alters brain development in mouse. Nat Neurosci. 2017 Aug;20(8):1062-1073
• All: 1 reference(s)