Kmt2c^em2Mgee
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kmt2c^em2Mgee
• Name: lysine (K)-specific methyltransferase 2C; endonuclease-mediated mutation 2, Jeffrey Magee
• MGI ID: MGI:6856518
• Synonyms: Kmt2c^-
• Gene: Kmt2c Location: Chr5:25476796-25703781 bp, - strand Genetic Position: Chr5, 12.35 cM
• Alliance: Kmt2c^em2Mgee page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to create a germline premature stop by deleting 5 bp in exon 14. Western blot analysis confirms the absence of protein. (J:312324)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2c Mutation: 182 strains or lines available

References

• Original: J:312324 Chen R, et al., Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy. Cell Rep. 2021 Feb 16;34(7):108751
• All: 1 reference(s)