Cops2^em1Frao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cops2^em1Frao
• Name: COP9 signalosome subunit 2; endonuclease-mediated mutation 1, Feng Rao
• MGI ID: MGI:6854725
• Synonyms: Csn2^K70E
• Gene: Cops2 Location: Chr2:125672222-125701002 bp, - strand Genetic Position: Chr2, 61.76 cM
• Alliance: Cops2^em1Frao page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a lysine to glutamate substitution at amino acid 70 (K70E) in exon 3. This change prevents inositol hexakisphosphate binding at this residue. (J:317457)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops2 Mutation: 18 strains or lines available

References

• Original: J:317457 Lin H, et al., IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. Nat Commun. 2021 Apr 28;12(1):2461
• All: 1 reference(s)