Mboat4^em1Gkun
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mboat4^em1Gkun
• Name: membrane bound O-acyltransferase domain containing 4; endonuclease-mediated mutation 1, George Kunos
• MGI ID: MGI:6854710
• Synonyms: Mboat4^-
• Gene: Mboat4 Location: Chr8:34582184-34592336 bp, + strand Genetic Position: Chr8, 20.9 cM
• Alliance: Mboat4^em1Gkun page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing is used to delete 6334 bp (corresponding to the region spanning from 27489 bp to 33823 bp) including exons 1 and 2. (J:275677)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mboat4 Mutation: 17 strains or lines available

References

• Original: J:275677 Godlewski G, et al., Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis. Cell Metab. 2019 Jun 4;29(6):1320-1333.e8
• All: 1 reference(s)