Scn1a^tm1Snhr
Targeted Allele Detail

Summary

• Symbol: Scn1a^tm1Snhr
• Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 1, Shinichi Hirose
• MGI ID: MGI:6854704
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^tm1Snhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 to 12 were replaced by a construct consisting of a lox71 site, FRT site, PPGK-neomycin resistance gene, lox2272 site, pA, and FRT site via homologous recombination. (J:317418)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 113 strains or lines available

References

• Original: J:317418 Uchino K, et al., Inhibitory synaptic transmission is impaired at higher extracellular Ca(2+) concentrations in Scn1a(+/-) mouse model of Dravet syndrome. Sci Rep. 2021 May 20;11(1):10634
• All: 2 reference(s)