Sirpa^tm1Ynliu
Targeted Allele Detail

Summary

• Symbol: Sirpa^tm1Ynliu
• Name: signal-regulatory protein alpha; targeted mutation 1, Yuan Liu
• MGI ID: MGI:6854701
• Synonyms: Sirpalpha^-
• Gene: Sirpa Location: Chr2:129434755-129474148 bp, + strand Genetic Position: Chr2, 63.19 cM, cytoband F3
• Alliance: Sirpa^tm1Ynliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238280
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C3H/HeN

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The targeting vector is designed to replace exons 2-4 with a neomycin resistance (neo) cassette. (J:238280)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirpa Mutation: 37 strains or lines available

References

• Original: J:238280 Bian Z, et al., Cd47-Sirpalpha interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5434-43
• All: 4 reference(s)