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Smpxem2Jgao
Endonuclease-mediated Allele Detail
Summary
Symbol: Smpxem2Jgao
Name: small muscle protein, X-linked; endonuclease-mediated mutation 1, Jiangang Gao
MGI ID: MGI:6852753
Gene: Smpx  Location: ChrX:156481969-156535587 bp, + strand  Genetic Position: ChrX, 72.67 cM
Alliance: Smpxem2Jgao page
Mutation
origin
Strain of Origin:  CBA/CaJ
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Insertion
 
Mutation detailsCRISPR/Cas9 technology generated a 620 bp insertion in the third exon. cDNA sequencing shows that the entire exon 3 (87 bp) is absent. (J:314284)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smpx Mutation:  3 strains or lines available
References
Original:  J:314284 Tu H, et al., SMPX Deficiency Causes Stereocilia Degeneration and Progressive Hearing Loss in CBA/CaJ Mice. Front Cell Dev Biol. 2021;9:750023
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory