Dock4^tm1.1Bcgen
Targeted Allele Detail

Summary

• Symbol: Dock4^tm1.1Bcgen
• Name: dedicator of cytokinesis 4; targeted mutation 1.1, Biocytogen LLC
• MGI ID: MGI:6850049
• Synonyms: Dock4^fl
• Gene: Dock4 Location: Chr12:40495956-40896873 bp, + strand Genetic Position: Chr12, 18.06 cM
• Alliance: Dock4^tm1.1Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316919
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 3 a loxP site and downstream of exon 3 an FRT-flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:316919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock4 Mutation: 108 strains or lines available

References

• Original: J:316919 Guo D, et al., Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Mol Psychiatry. 2021 May;26(5):1505-1519
• All: 1 reference(s)