Nf2^tm1.1Fxyu
Targeted Allele Detail

Summary

• Symbol: Nf2^tm1.1Fxyu
• Name: neurofibromin 2; targeted mutation 1.1, Fa-Xing Yu
• MGI ID: MGI:6850048
• Synonyms: Nf2^f
• Gene: Nf2 Location: Chr11:4715845-4799536 bp, - strand Genetic Position: Chr11, 3.0 cM
• Alliance: Nf2^tm1.1Fxyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316925
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 5 an Rox-flanked neomycin resistance cassette with a 5 prime loxP site and an additional loxP site downstream of exon 6. Dre-mediated recombination removed the selection cassette and left exons 5 and 6. (J:316925)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nf2 Mutation: 67 strains or lines available

References

• Original: J:316925 Wang Y, et al., Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis. Cell Rep. 2021 Aug 24;36(8):109596
• All: 4 reference(s)