Xrcc4^em1Jpdv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Xrcc4^em1Jpdv
• Name: X-ray repair complementing 4; endonuclease-mediated mutation 1, Jean-Pierre de Villartay
• MGI ID: MGI:6849973
• Synonyms: Xrcc4^M61R
• Gene: Xrcc4 Location: Chr13:89997033-90237727 bp, - strand Genetic Position: Chr13, 45.5 cM
• Alliance: Xrcc4^em1Jpdv page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation encoding the amino acid substitution of methionine to arginine at position 61 (M61R). (J:316933)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc4 Mutation: 27 strains or lines available

References

• Original: J:316933 Roch B, et al., An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development. Elife. 2021 Sep 14;10:e69353
• All: 1 reference(s)