Tigit^em1Shib
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tigit^em1Shib
• Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 1, Akira Shibuya
• MGI ID: MGI:6845050
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^em1Shib page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 5 bp deletion (AAGTC) in exon 2. (J:289231)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 27 strains or lines available

References

• Original: J:289231 Negishi N, et al., CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity. Immunohorizons. 2018 Nov 16;2(10):338-348
• All: 3 reference(s)