Pdia6^m1Mhda
Chemically induced Allele Detail

Summary

• Symbol: Pdia6^m1Mhda
• Name: protein disulfide isomerase associated 6; mutation 1, Martin Hrabe de Angelis
• MGI ID: MGI:6842431
• Synonyms: Pdia6^F175S, Pdia6^F175SMhda
• Gene: Pdia6 Location: Chr12:17316590-17334786 bp, + strand Genetic Position: Chr12, 8.06 cM
• Alliance: Pdia6^m1Mhda page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to C point mutation that results in the amino acid substitution of phenylalanine to serine at position 175 (F175S). (J:312492)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdia6 Mutation: 30 strains or lines available

References

• Original: J:312492 Chhabra NF, et al., A point mutation in the Pdia6 gene results in loss of pancreatic beta-cell identity causing overt diabetes. Mol Metab. 2021 Sep 4;54:101334
• All: 1 reference(s)