Morc3^tm1.1Hko
Targeted Allele Detail

Summary

• Symbol: Morc3^tm1.1Hko
• Name: microrchidia 3; targeted mutation 1.1, Haruhiko Koseki
• MGI ID: MGI:6842430
• Gene: Morc3 Location: Chr16:93629009-93672961 bp, + strand Genetic Position: Chr16, 54.88 cM
• Alliance: Morc3^tm1.1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312495
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP site upstream of exon2 and an FRT-flanked neomycin resistance cassette with a 3 prime loxP site downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:312495)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Morc3 Mutation: 78 strains or lines available

Notes

ES cells originated from lab-made hybrid embryos derived from C57BL/6J and C57BL/6N mice.

References

• Original: J:312495 Kojima-Kita K, et al., MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells. Sci Rep. 2021 Oct 14;11(1):20472
• All: 1 reference(s)