Meiob^em4Jw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Meiob^em4Jw
• Name: meiosis specific with OB domains; endonuclease-mediated mutation 4, Jeremy Wang
• MGI ID: MGI:6842366
• Synonyms: Meiob^N64I
• Gene: Meiob Location: Chr17:25023275-25058762 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Meiob^em4Jw page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a AT to TC nucleotide substitution that mimics a human mutation and results in the amino acid substitution of asparagine to isoleucine at position 64 (N64I). (J:298124)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meiob Mutation: 30 strains or lines available

References

• Original: J:298124 Guo R, et al., The ssDNA-binding protein MEIOB acts as a dosage-sensitive regulator of meiotic recombination. Nucleic Acids Res. 2020 Dec 2;48(21):12219-12233
• All: 1 reference(s)