Meiob^em1Jw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Meiob^em1Jw
• Name: meiosis specific with OB domains; endonuclease-mediated mutation 1, Jeremy Wang
• MGI ID: MGI:6842363
• Synonyms: Meiob^D383A
• Gene: Meiob Location: Chr17:25023275-25058762 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Meiob^em1Jw page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas technology generated a AC to CG nucleotide substitution and results in the amino acid substitution of aspartic acid to alanine at position 383 (D383A). (J:297076)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meiob Mutation: 30 strains or lines available

References

• Original: J:297076 Xu Y, et al., A cell-based high-content screen identifies isocotoin as a small molecule inhibitor of the meiosis-specific MEIOB-SPATA22 complex. Biol Reprod. 2020 Aug 4;103(2):333-342
• All: 1 reference(s)