Ythdc2^tm1Jw
Targeted Allele Detail

Summary

• Symbol: Ythdc2^tm1Jw
• Name: YTH domain containing 2; targeted mutation 1, Jeremy Wang
• MGI ID: MGI:6842333
• Synonyms: Ythdc2^fl
• Gene: Ythdc2 Location: Chr18:44961521-45022782 bp, + strand Genetic Position: Chr18, 23.81 cM
• Alliance: Ythdc2^tm1Jw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316789
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 13-16 are flanked by loxP sites. Deletion of exons 13-16 results in a deletion of 149 amino acids (amino acids 578 to 726) and a frame shift in the mutant transcript. (J:316789)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ythdc2 Mutation: 58 strains or lines available

References

• Original: J:316789 Liu R, et al., YTHDC2 is essential for pachytene progression and prevents aberrant microtubule-driven telomere clustering in male meiosis. Cell Rep. 2021;37(11):110110
• All: 1 reference(s)