About   Help   FAQ
Endonuclease-mediated Allele Detail
Symbol: Ace2em1(ACE2)Mlkn
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; endonuclease-mediated mutation 1, Mark L Kahn
MGI ID: MGI:6842318
Synonyms: hACE2fl
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance: Ace2em1(ACE2)Mlkn page
Germline Transmission:  Earliest citation of germline transmission: J:315719
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Endonuclease-mediated (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
Ace2em1(ACE2)Mlkn expresses 1 gene
Mutation detailsCRISPR/cas9 meditated recombination inserted a cassette containing a modified human ACE2 cDNA, loxP site, woodchuck hepatitis virus post-transcriptional regulatory element, simian virus 40 polyA sequence, loxP site, and an FRT-flanked PGK-neo and loxP site directly after the ATG site in exon 2. The human ACE2 cDNA was modified to use the mouse Ace2 signal peptide and codon-optimized for a mouse. (J:315719)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  36 strains or lines available
Original:  J:315719 Tang AT, et al., SARS-CoV-2 infection olfactory cells and neurons drives acute lung injury and lethal COVID-19 in mice. bioRxiv. 2021 Dec;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory