Pdha1^em1.1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pdha1^em1.1Cya
• Name: pyruvate dehydrogenase E1 alpha 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6842312
• Synonyms: Pdha1^em1.1Cgen
• Gene: Pdha1 Location: ChrX:158905205-158921409 bp, - strand Genetic Position: ChrX, 73.95 cM, cytoband F3-F4
• Alliance: Pdha1^em1.1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a loxP site upstream of exon 4 and a rox-flanked neomycin resistance cassette with a 3 prime loxP site downstream of exon 4. Dre-mediated recombination removed the selection cassette and left exon 4 floxed. (J:312681)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdha1 Mutation: 25 strains or lines available

References

• Original: J:312681 Chen W, et al., Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate. Front Neurosci. 2021;15:767560
• All: 1 reference(s)