Scn1a^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Scn1a^tm1.1Arte
• Name: sodium channel, voltage-gated, type I, alpha; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6840236
• Synonyms: Scn1a^L1649Q, Scn1a^mut
• Gene: Scn1a Location: Chr2:66101125-66271181 bp, - strand Genetic Position: Chr2, 39.13 cM
• Alliance: Scn1a^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:313063
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct introduced the amino acid substitution of leucine for glutamine at position 1649 (L1649Q). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:313063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1a Mutation: 113 strains or lines available

References

• Original: J:313063 Auffenberg E, et al., Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model. J Clin Invest. 2021 Nov 1;131(21):e142202
• All: 1 reference(s)