Kalrn^em1Swtra
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kalrn^em1Swtra
• Name: kalirin, RhoGEF kinase; endonuclease-mediated mutation 1, Robert A Sweet
• MGI ID: MGI:6840227
• Gene: Kalrn Location: Chr16:33789443-34393647 bp, - strand Genetic Position: Chr16, 24.27 cM
• Alliance: Kalrn^em1Swtra page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced a point mutation (CCC to ACT) that results in the amino acid substitution of proline with threonine in addition to a silent mutation. This mutation has been identified in patients with schizophrenia. (J:316319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kalrn Mutation: 171 strains or lines available

References

• Original: J:316319 Grubisha MJ, et al., A Kalirin missense mutation enhances dendritic RhoA signaling and leads to regression of cortical dendritic arbors across development. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2022546118
• All: 1 reference(s)