Ntrk2^tm3.1Mini
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm3.1Mini
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 3.1, Liliana Minichiello
• MGI ID: MGI:6840223
• Synonyms: Trka^fl
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm3.1Mini page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130626
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 12 a loxP site and downstream of exon 14 a loxP site, and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:130626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 63 strains or lines available

References

• Original: J:130626 Minichiello L, et al., Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002 Sep 26;36(1):121-37
• All: 2 reference(s)