Nfkb2^em1Macc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nfkb2^em1Macc
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; endonuclease-mediated mutation 1, Matthew C Cook
• MGI ID: MGI:6835770
• Synonyms: Nfkb2^D865G
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^em1Macc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 22 produced the amino acid substitution of aspartic acid for glycine at position 865 (D865G in XP_006526806.1; 864 in uniport Q9WTK5) and a silent mutation in the protospacer-associated motif sequence (GGG to GGA). (J:313325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 51 strains or lines available

References

• Original: J:313325 Wirasinha RC, et al., Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility. J Exp Med. 2021 Feb 1;218(2)
• All: 1 reference(s)