Fn1^tm3.1Ref
Targeted Allele Detail

Summary

• Symbol: Fn1^tm3.1Ref
• Name: fibronectin 1; targeted mutation 3.1, Reinhard Fassler
• MGI ID: MGI:6835637
• Gene: Fn1 Location: Chr1:71624679-71692359 bp, - strand Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
• Alliance: Fn1^tm3.1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:313430
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: Site directed mutagenesis deleted the RGD coding sequence in exon 30. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 30. (J:313430)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fn1 Mutation: 130 strains or lines available

References

• Original: J:313430 Benito-Jardon M, et al., alphav-Class integrin binding to fibronectin is solely mediated by RGD and unaffected by an RGE mutation. J Cell Biol. 2020 Dec 7;219(12)
• All: 1 reference(s)