Taok3^em3Bnlt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Taok3^em3Bnlt
• Name: TAO kinase 3; endonuclease-mediated mutation 3, Bart N Lambrecht
• MGI ID: MGI:6834817
• Synonyms: Taok3^KD
• Gene: Taok3 Location: Chr5:117258194-117413284 bp, + strand Genetic Position: Chr5, 56.88 cM
• Alliance: Taok3^em3Bnlt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 4 produced an AAG-to-GCC mutation that caused a lysine to alanine mutation in position 53 (K53A). This allele produces a kinase dead protein. (J:313593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taok3 Mutation: 53 strains or lines available

References

• Original: J:313593 Maes B, et al., The STE20 kinase TAOK3 controls the development house dust mite-induced asthma in mice. J Allergy Clin Immunol. 2021 Sep 8
• All: 2 reference(s)