Stat3^tm7Smoc
Targeted Allele Detail

Summary

• Symbol: Stat3^tm7Smoc
• Name: signal transducer and activator of transcription 3; targeted mutation 7, Shanghai Model Organisms Center
• MGI ID: MGI:6834800
• Synonyms: Stat3^fl, Stat3^{tm7(flox)Smoc}
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm7Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:313672
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The targeting construct flanked exons 12 through 14. (J:313672)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:313672 Wang J, et al., Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling. Nat Commun. 2021 Oct 27;12(1):6198
• All: 1 reference(s)