Diaph1^{tm1(DIAPH1/AcGFP)Kobio}
Targeted Allele Detail

Summary

• Symbol: Diaph1^{tm1(DIAPH1/AcGFP)Kobio}
• Name: diaphanous related formin 1; targeted mutation 1, Biosignal Research Center, Kobe University
• MGI ID: MGI:6833994
• Synonyms: DIA1^KI
• Gene: Diaph1 Location: Chr18:37976654-38068529 bp, - strand Genetic Position: Chr18, 19.71 cM
• Alliance: Diaph1^{tm1(DIAPH1/AcGFP)Kobio} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314141
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Diaph1^{tm1(DIAPH1/AcGFP)Kobio} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DIAPH1 (1729)

  Diaph1

  (MGI:1194490)

  human sequence with the R1213* (arginine to a stop codon at position 1213) mutation and a C-terminal AcGFP reporter gene

• Mutation details: The targeting construct introduced into the locus before the translation initiation codon the human sequence with the R1213* (arginine to a stop codon at position 1213) mutation and a C-terminal AcGFP reporter gene following by a polyadenylation sequence and an FRT-flanked neomycin resistance cassette. (J:314141)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Diaph1 Mutation: 117 strains or lines available

References

• Original: J:314141 Ninoyu Y, et al., The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia. Cell Death Dis. 2020 Jul 16;11(7):536
• All: 1 reference(s)