Fundc1^em1.1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fundc1^em1.1Gpt
• Name: FUN14 domain containing 1; endonuclease-mediated mutation 1.1, GemPharmatech Co., Ltd
• MGI ID: MGI:6833989
• Gene: Fundc1 Location: ChrX:17422803-17438564 bp, - strand Genetic Position: ChrX, 12.8 cM, cytoband A2
• Alliance: Fundc1^em1.1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 to 5 were flanked by loxP sites using CRISPR/Cas9 technology. Cre-mediated recombination removed exons 1 through 5. (J:293217)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fundc1 Mutation: 10 strains or lines available

References

• Original: J:307071 Liu L, et al., Mitophagy receptor FUNDC1 is regulated by PGC-1alpha/NRF1 to fine tune mitochondrial homeostasis. EMBO Rep. 2021 Mar 3;22(3):e50629
• All: 5 reference(s)