Havcr2^tm1.1Kuch
Targeted Allele Detail

Summary

• Symbol: Havcr2^tm1.1Kuch
• Name: hepatitis A virus cellular receptor 2; targeted mutation 1.1, Vijay K Kuchroo
• MGI ID: MGI:6833984
• Synonyms: Havcr2^fl
• Gene: Havcr2 Location: Chr11:46345762-46372082 bp, + strand Genetic Position: Chr11, 27.9 cM
• Alliance: Havcr2^tm1.1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314511
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 1 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon1. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:314511)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Havcr2 Mutation: 30 strains or lines available

References

• Original: J:314511 Dixon KO, et al., TIM-3 restrains anti-tumour immunity by regulating inflammasome activation. Nature. 2021 Jul;595(7865):101-106
• All: 2 reference(s)