Alkbh2^tm1Troc
Targeted Allele Detail

Summary

• Symbol: Alkbh2^tm1Troc
• Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase; targeted mutation 1, Timothy R O'Connor
• MGI ID: MGI:6833879
• Synonyms: Alkbh2^-
• Gene: Alkbh2 Location: Chr5:114261987-114266279 bp, - strand Genetic Position: Chr5, 55.97 cM
• Alliance: Alkbh2^tm1Troc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316069
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Targeted disruption was performed in Y129 mouse embryonic stem cells (mESCs) to replace exon 4 that contains critical active site residues with a PGK-Neo cassette in the Alkbh2 gene. (J:316069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alkbh2 Mutation: 69 strains or lines available

References

• Original: J:316069 Nay SL, et al., Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts. DNA Repair (Amst). 2012 May 1;11(5):502-10
• All: 1 reference(s)