Actn2^tm1Begg
Targeted Allele Detail

Summary

• Symbol: Actn2^tm1Begg
• Name: actinin alpha 2; targeted mutation 1, Alan Beggs
• MGI ID: MGI:6833863
• Synonyms: Actn2^F
• Gene: Actn2 Location: Chr13:12284312-12355613 bp, - strand Genetic Position: Chr13, 4.54 cM
• Alliance: Actn2^tm1Begg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299963
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 2 and a loxP-flanked neomycin resistance cassette downstream of exon 4. (J:299963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Actn2 Mutation: 58 strains or lines available

Notes

ES cell = IC1

References

• Original: J:299963 Guo Y, et al., Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2008861118
• All: 1 reference(s)