Kmt2c^em1Chdy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kmt2c^em1Chdy
• Name: lysine (K)-specific methyltransferase 2C; endonuclease-mediated mutation 1, Sarat Chandarlapaty
• MGI ID: MGI:6833855
• Gene: Kmt2c Location: Chr5:25476796-25703781 bp, - strand Genetic Position: Chr5, 12.35 cM
• Alliance: Kmt2c^em1Chdy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting floxed exon 3. (J:316063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2c Mutation: 182 strains or lines available

References

• Original: J:316063 Gala K, et al., KMT2C mediates the estrogen dependence of breast cancer through regulation of ERalpha enhancer function. Oncogene. 2018;37(34):4692-4710
• All: 2 reference(s)