Mlkl^em1Wehi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em1Wehi
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Walter and Eliza Hall Institute of Medical Research
• MGI ID: MGI:6833852
• Synonyms: Mlkl^D139V
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em1Wehi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Constitutively active)
• Mutation: Single point mutation
• CRISPR-targeting inserted the amino acid substitution aspartate to valine with 139 (D139V). (J:292274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:292274 Hildebrand JM, et al., A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nat Commun. 2020 Jun 19;11(1):3150
• All: 2 reference(s)