Casp8^tm1.1Hed
Targeted Allele Detail

Summary

• Symbol: Casp8^tm1.1Hed
• Name: caspase 8; targeted mutation 1.1, Stephen M Hedrick
• MGI ID: MGI:6833851
• Gene: Casp8 Location: Chr1:58834553-58886663 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^tm1.1Hed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292274
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked with loxP sites by homologous recombination. Cre-mediated recombination removed exon 3. (J:292274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 45 strains or lines available

References

• Original: J:292274 Hildebrand JM, et al., A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nat Commun. 2020 Jun 19;11(1):3150
• All: 1 reference(s)