Trp53^tm4.1Wgu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm4.1Wgu
• Name: transformation related protein 53; targeted mutation 4.1, Wei Gu
• MGI ID: MGI:6831629
• Synonyms: p53-4KR
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm4.1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314680
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Lysine codons 98 (AAA), 117 (AAG), 160 (AAG), and 161 (AAG) were changed to arginine (p.K98R + p.K117R + p.K160R + p.K161R). Cre-mediated recombination removed the loxP site flanked neomycin resistance gene cassette that was inserted into intron 4. (J:314680)

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:314680 Kon N, et al., mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression. Genes Dev. 2021 Jan 1;35(1-2):59-64
• All: 1 reference(s)