Slfn2^tm1.1Btlr
Targeted Allele Detail

Summary

• Symbol: Slfn2^tm1.1Btlr
• Name: schlafen 2; targeted mutation 1.1, Bruce Beutler
• MGI ID: MGI:6831155
• Synonyms: Slfn2^f
• Gene: Slfn2 Location: Chr11:82955938-82961504 bp, + strand Genetic Position: Chr11, 50.3 cM
• Alliance: Slfn2^tm1.1Btlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314967
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP site upstream of exon 2 and an FRT flanked neomycin resistance cassette with a 3' loxP site. Cre-mediated recombination removed the selection cassette. (J:314967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slfn2 Mutation: 16 strains or lines available

References

• Original: J:314967 Yue T, et al., SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity. Science. 2021 May 14;372(6543)
• All: 1 reference(s)