Inf2^tm2.1Vlcg
Targeted Allele Detail

Summary

• Symbol: Inf2^tm2.1Vlcg
• Name: inverted formin, FH2 and WH2 domain containing; targeted mutation 2.1, Velocigene
• MGI ID: MGI:6831154
• Synonyms: INF2 KI, Inf2^R218Q
• Gene: Inf2 Location: Chr12:112555218-112581991 bp, + strand Genetic Position: Chr12, 61.2 cM
• Alliance: Inf2^tm2.1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314968
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct inserted a floxed neomycin resistance cassette into intro 4 and the point mutation CGG to CAG that produces the amino acid substitution arginine to glutamine at position 218 (R218Q). Cre-mediated recombination removed the selection cassette. (J:314968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inf2 Mutation: 49 strains or lines available

References

• Original: J:314968 Subramanian B, et al., Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury. Kidney Int. 2016 Aug;90(2):363-372
• All: 1 reference(s)