Sart3^tm1.3Jjhe
Targeted Allele Detail

Summary

• Symbol: Sart3^tm1.3Jjhe
• Name: squamous cell carcinoma antigen recognized by T cells 3; targeted mutation 1.3, Johnny J He
• MGI ID: MGI:6830965
• Synonyms: Tip110^KD
• Gene: Sart3 Location: Chr5:113880505-113910461 bp, - strand Genetic Position: Chr5, 55.55 cM
• Alliance: Sart3^tm1.3Jjhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253448
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Knockdown)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a floxed neomycin resistance cassette upstream of exon 12 and an additional loxP site downstream of exon 18. Exon 12 was inadvertently deleted in the original targeting construct. Cre-mediated recombination removed the floxed selection cassette. Deleted of exon 12 produces a frame shift and premature termination in exon 13. (J:253448)

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sart3 Mutation: 46 strains or lines available

References

• Original: J:253448 Whitmill A, et al., Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Stem Cells. 2017 Jul;35(7):1674-1686
• All: 1 reference(s)