Tmem176b^tm2.1Ics
Targeted Allele Detail

Summary

• Symbol: Tmem176b^tm2.1Ics
• Name: transmembrane protein 176B; targeted mutation 2.1, Mouse Clinical Institute
• MGI ID: MGI:6830518
• Synonyms: Tmem176a/b^fl
• Gene: Tmem176b Location: Chr6:48810745-48818363 bp, - strand Genetic Position: Chr6, 23.75 cM
• Alliance: Tmem176b^tm2.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315063
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted an FRT-flanked neomycin resistance cassette with a 5' loxP site downstream of the second coding exon. Flp-mediated recombination removed the selection cassette. (J:315063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem176b Mutation: 22 strains or lines available

References

• Original: J:315063 Lancien M, et al., Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4(+) T Cells. J Immunol. 2021 Jul 7
• All: 1 reference(s)