Prdm9^tm2.1Kpgn
Targeted Allele Detail

Summary

• Symbol: Prdm9^tm2.1Kpgn
• Name: PR domain containing 9; targeted mutation 2.1 Kenneth Paigen
• MGI ID: MGI:6830506
• Synonyms: Prdm9^Set-, Set-
• Gene: Prdm9 Location: Chr17:15763341-15784616 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Prdm9^tm2.1Kpgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314361
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: A point mutation was introduced causing a p.G274A substitution, which results in the loss of PR/SET domain methylation activity. (J:314361)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm9 Mutation: 45 strains or lines available

References

• Original: J:314361 Tian H, et al., EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8. Mol Biol Cell. 2021 Jan 1;32(1):1-14
• All: 1 reference(s)