U2af1^tm1.1Mjwa
Targeted Allele Detail

Summary

• Symbol: U2af1^tm1.1Mjwa
• Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1; targeted mutation 1.1, Matthew Walter
• MGI ID: MGI:6829667
• Synonyms: U2af1^fl
• Gene: U2af1 Location: Chr17:31866055-31877866 bp, - strand Genetic Position: Chr17, 17.02 cM
• Alliance: U2af1^tm1.1Mjwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct contains a loxP site in intron 1 and an FRT-loxP-neomycin-FRT-loxP cassette placed in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:315006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any U2af1 Mutation: 33 strains or lines available

References

• Original: J:315006 Wadugu BA, et al., U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice. J Clin Invest. 2021 Nov 1;131(21):e141401
• All: 1 reference(s)