Tg(Alb-TFRC/OVAL)1Pmall
Transgene Detail

Summary

• Symbol: Tg(Alb-TFRC/OVAL)1Pmall
• Name: transgene insertion 1, Paul M Allen
• MGI ID: MGI:6828955
• Synonyms: OVA-HEP
• Transgene: Tg(Alb-TFRC/OVAL)1Pmall Location: unknown
• Alliance: Tg(Alb-TFRC/OVAL)1Pmall page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-TFRC/OVAL)1Pmall expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  chicken

  OVAL (396058)

  human TFRC fused to OVAL

  human

  TFRC (7037)

  Tfrc	(MGI:98822)

  human TFRC fused to OVAL

• Mutation details: The transgenic construct contains the mouse Alb (albumin) promoter driving expression of the first 118 residues of the human transferrin receptor (TFRC; including the cytoplasmic tail and signal/ancho domain) fused to residues 139-385 of mature chicken ovalbumin cDNA and a polyA tail. The transgene expresses a membrane bound form of ovalbumin o hepatocytes. (J:314920)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:314920 Buxbaum J, et al., Hepatitis resulting from liver-specific expression and recognition of self-antigen. J Autoimmun. 2008 Nov;31(3):208-15
• All: 1 reference(s)