Gt(ROSA)26Sor^{tm1(CAG-NTN1)Atp}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-NTN1)Atp}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Andreas Trumpp
• MGI ID: MGI:6827295
• Synonyms: LSL-Rosa26-Ntn1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-NTN1)Atp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301277
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A conditional over-expression cassette was inserted into the locus. The cassette contains a CAG promoter, floxed STOP cassette, and human NTN1and polyadenylation sequence. (J:301277)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:301277 Renders S, et al., Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1. Nat Commun. 2021 Jan 27;12(1):608
• All: 2 reference(s)