Prkcetm1.1Akv
Targeted Allele Detail
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Symbol: |
Prkcetm1.1Akv |
Name: |
protein kinase C, epsilon; targeted mutation 1.1, Ajit K Verma |
MGI ID: |
MGI:6827171 |
Synonyms: |
PKCepsilonLoxP |
Gene: |
Prkce Location: Chr17:86475213-86965347 bp, + strand Genetic Position: Chr17, 56.74 cM
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Alliance: |
Prkcetm1.1Akv page
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Germline Transmission: |
Earliest citation of germline transmission:
J:314542
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Parent Cell Line: |
JM8A3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The targeting construct is designed to insert a loxP site upstream of exon 4 and a second loxP site, followed by an FRT-flanked neomycin downstream of exon 4. Removal of exon 4 results in a frameshift and the premature truncation of protein. Flp-mediated recombination removed the FRT-flanked neo cassette.
(J:314542)
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Original: |
J:314542 Hafeez BB, et al., Tissue-specific conditional PKCepsilon knockout mice: a model to precisely reveal PKCepsilon functional role in initiation, promotion and progression of cancer. Oncotarget. 2016 May 31;7(22):33069-80 |
All: |
1 reference(s) |
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