Grxcr2^em3Bzha
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grxcr2^em3Bzha
• Name: glutaredoxin, cysteine rich 2; endonuclease-mediated mutation 3, Bo Zhao
• MGI ID: MGI:6822326
• Synonyms: Grxcr2^D180
• Gene: Grxcr2 Location: Chr18:42118388-42132114 bp, - strand Genetic Position: Chr18, 22.14 cM
• Alliance: Grxcr2^em3Bzha page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 180 bp deletion in exon 1 near the N-terminus that is essential for its interaction with CLIC5, resulting in a change of amino acid sequence after residue 35, a loss of 60 amino acids, and remaining in frame. (J:314281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grxcr2 Mutation: 12 strains or lines available

References

• Original: J:314281 Li J, et al., N-Terminus of GRXCR2 Interacts With CLIC5 and Is Essential for Auditory Perception. Front Cell Dev Biol. 2021;9:671364
• All: 1 reference(s)