Ctss^em1Narl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ctss^em1Narl
• Name: cathepsin S; endonuclease-mediated mutation 1, National Laboratory Animal Center
• MGI ID: MGI:6818656
• Gene: Ctss Location: Chr3:95434097-95463714 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctss^em1Narl page

Mutation origin

• Strain of Origin: C57BL/6JNarl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced several mutations (atgcccctggtg to atgTGActAgtg), including a stop codon, in exon 2 right after the transcription start site to inhibit RNA and protein expression. (J:314270)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctss Mutation: 33 strains or lines available

References

• Original: J:314270 Chen SJ, et al., Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy. Theranostics. 2021;11(10):4672-4687
• All: 1 reference(s)