Emilin2^tm1Monm
Targeted Allele Detail

Summary

• Symbol: Emilin2^tm1Monm
• Name: elastin microfibril interfacer 2; targeted mutation 1, Maurizio Mongiat
• MGI ID: MGI:6810783
• Gene: Emilin2 Location: Chr17:71559167-71618551 bp, - strand Genetic Position: Chr17, 41.87 cM
• Alliance: Emilin2^tm1Monm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314039
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance gene replaced a 684 bp long region consisting of part of exon 1, including the translation start site, and a portion of the first intron via homologous recombination. (J:314039)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Emilin2 Mutation: 56 strains or lines available

References

• Original: J:314039 Paulitti A, et al., The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth. Oncogene. 2018 Jun;37(25):3399-3414
• All: 3 reference(s)