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Transgene Detail
Symbol: Tg(Thy1-SNCA*)#Ztzh
Name: transgene insertion, Zhentao Zhang
MGI ID: MGI:6810775
Synonyms: N103
Transgene: Tg(Thy1-SNCA*)#Ztzh  Location: unknown  
Alliance: Tg(Thy1-SNCA*)#Ztzh page
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-SNCA*)#Ztzh expresses 1 gene
Mutation detailsA fragment of the human alpha-synuclein 1-130 (an N-terminal fragment generated by aberrantly activated asparagine endopeptidase which cleaves alpha-synuclein at N103 and which is prone to aggregate and cause neurotoxicity) cDNA with its 5' UTR containing a Kozak enhance sequence before the initial codon and the 3' polyA tail is under the control of the neuron-specific Thy1 promoter. Western blot analysis confirmed expression of the 1-130 fragment in the brain and showed that the insoluble fragment is enriched in the olfactory bulb, cortex, striatum, substantia nigra, and pons. Insoluble alpha-synuclein phosphorylated at Ser129 is detected within all areas of the central nervous system. Two founders with high expression were used to generate lines. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:313970)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:313970 Tian Y, et al., Transgenic Mice Expressing Human alpha-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease. Front Aging Neurosci. 2021;13:760781
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory