Keap1^em4Mym
Endonuclease-mediated Allele Detail

Summary

• Symbol: Keap1^em4Mym
• Name: kelch-like ECH-associated protein 1; endonuclease-mediated mutation 4, Masayuki Yamamoto
• MGI ID: MGI:6791326
• Synonyms: Keap1^C226S
• Gene: Keap1 Location: Chr9:21141026-21150628 bp, - strand Genetic Position: Chr9, 7.74 cM, cytoband A3
• Alliance: Keap1^em4Mym page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the amino acid substitution of cysteine with serine at position 226 (C226S). (J:284404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Keap1 Mutation: 34 strains or lines available

References

• Original: J:284404 Suzuki T, et al., Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1. Cell Rep. 2019 Jul 16;28(3):746-758.e4
• All: 2 reference(s)