Igsf11^em1Kee
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igsf11^em1Kee
• Name: immunoglobulin superfamily, member 11; endonuclease-mediated mutation 1, Kehkooi Kee
• MGI ID: MGI:6791320
• Gene: Igsf11 Location: Chr16:38713033-38847521 bp, + strand Genetic Position: Chr16, 26.87 cM
• Alliance: Igsf11^em1Kee page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 19 bp deletion (GGCCCGGGGCCAGACAGCA) in exon 2 leading to a frameshift mutation and premature translation termination. Western blot analysis confirmed absence of protein in testes. (J:310334)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igsf11 Mutation: 33 strains or lines available

References

• Original: J:310334 Chen B, et al., IGSF11 is required for pericentric heterochromatin dissociation during meiotic diplotene. PLoS Genet. 2021 Sep;17(9):e1009778
• All: 1 reference(s)